02495nas a2200193   4500008004100000020001400041245009500055210006900150260000900219300000900228490000700237520180400244100002102048700002202069700001902091700002802110700002302138856014002161       2007                        eng d  a0146-040400aExtraction of an Age-Related Biomarker From Retinal Images Using Appearance Based Approach0 aExtraction of an AgeRelated Biomarker From Retinal Images Using   c2007  a21670 v483 a<p>Purpose:To develop an appropriate algorithm from retina imagesusing an appearance-based version of the Principal Component Analysis and to test the age-related biomarker’s significance for patients at cardiovascular risk. Methods:Sixty-five men (age, 44.2 ± 11.4 years) and 60 women (age, 48.8 ± 12.6 years) without cardiovascular risk factors and without pathologic eye diagnosis were acquired during a clinical non-experimental cross-sectional survey and represented the control group. Forty-four hypertensive men (age, 45.5 ± 9.4 years; hypertensive for 5.9 ± 6.7 years) and 26 hypertensive women (age, 51.2 ± 7.3 years; hypertensive for 7.9 ± 7.1 years) as well as 57 male smokers (age, 41.8 ± 8.5 years; smoking for 20.6 ± 9.8 years; 15.3 ± 8.6 cigarettes per day) and 60 female smokers (age, 43.2 ± 9.5 years; smoking for 20.1 ± 10.7 years; 13.5 ± 8.1 cigarettes per day) were matched for age and sex to the respective number of control subjects. Results:The reliability of the algorithm was 0.958. The retinal biomarker correlated with age (men, -0.284, p = 0.017; women, -0.374, p = 0.001). Smokers showed a lower biomarker value (male, -0.16 ± 1.29; female, -0.12 ± 0.11) than age-matched control subjects (male, 0.72 ± 0.92, p &lt; 0.001; female, 0.24 ± 0.98, p = 0.048). Hypertension had a similar influence to the biomarker in men (0.10 ± 0.84), but not in women (-0.46 ± 1.23) as compared to age-matched controls (male, 0.57 ± 0.95, p = 0.01; female, 0.06 ± 0.99, p = 0.09). Conclusions:The algorithm of the appearance-based version of the Principal Component Analysis identified an age-related image feature dependent on light intensity with a strong influence to the temporal parapapillary area. It may be used to identify patients at cardiovascular risk.</p>1 aMichelson, Georg1 aWärntges, Simone1 aBock, Rudriger1 aNyúl, László, Gábor1 aHornegger, Joachim  uhttps://tisat.inf.u-szeged.hu/en/publication/extraction-of-an-age-related-biomarker-from-retinal-images-using-appearance-based-approach