01828nas a2200133   4500008004100000020001400041245010900055210006900164260001200233300001400245490000800259520138100267856004601648       2000                        eng d  a0033-841900aMultiple sclerosis: Magnetization transfer histogram analysis of segmented normal-appearing white matter0 aMultiple sclerosis Magnetization transfer histogram analysis of   c2000///  a351 - 3550 v2163 aPURPOSE: To investigate and characterize the global distributionof magnetization transfer (MT) ratio values of normal-appearing 
white matter (NAWM) in patients with relapsing-remitting 
multiple sclerosis (MS) and test the hypothesis that the MT 
histogram for NAWM reflects disease progression. MATERIALS AND 
METHODS: Conventional and MT magnetic resonance (MR) images were 
obtained in 23 patients and 25 healthy volunteers. Clinical 
tests for comparison with the MT histogram parameters included 
the Extended Disability Status Scale and the ambulation index. 
Lesion load calculated with T2-weighted MR images and whole-
brain and white matter volumes were measured. RESULTS: The 
location of the MT histogram peak and the mean MT ratio for NAWM 
were significantly lower in patients with MS than in control 
subjects. In longitudinal studies, the histogram peak location 
and mean MT ratio shifted in the direction of normal values as 
the duration of disease increased. A mean of 26.5% of the volume 
of new lesions identified on the later studies were demonstrated 
to have originated in NAWM corresponding to "lost" pixels on the 
histogram. CONCLUSION: MT histogram analysis of NAWM, including 
longitudinal analysis, may provide new prognostic information 
regarding lesion formation and increase understanding of the 
course of the disease.
  uhttps://tisat.inf.u-szeged.hu/en/node/99401538nas a2200133   4500008004100000020001400041245005800055210005800113260001200171300001400183490000700197520115400204856004601358       2000                        eng d  a0278-006200aNew variants of a method of MRI scale standardization0 aNew variants of a method of MRI scale standardization  c2000///  a143 - 1500 v193 aOne of the major drawbacks of magnetic resonance imaging (MRI)has been the lack of a standard and quantifiable interpretation 
of image intensities. Unlike in other modalities, such as X-ray 
computerized tomography, MR images taken for the same patient on 
the same scanner at different times may appear different from 
each other due to a variety of scanner-dependent variations and, 
therefore, the absolute intensity values do not have a fixed 
meaning. We have devised a two-step method wherein all images 
(independent of patients and the specific brand of the MR 
scanner used) can be transformed in such a way that for the same 
protocol and body region, in the transformed images similar 
intensities will have similar tissue meaning. Standardized 
images can be displayed with fixed windows without the need of 
per-case adjustment. More importantly, extraction of 
quantitative information about healthy organs or about 
abnormalities can be considerably simplified. This paper 
introduces and compares new variants of this standardizing 
method that can help to overcome some of the problems with the 
original method.
  uhttps://tisat.inf.u-szeged.hu/en/node/99500367nas a2200085   4500008004100000245011200041210006900153260001200222856004700234       1999                        eng d00aMagnetization Transfer Histogram Analysis of Segmented Normal- Appearing White Matter in Multiple Sclerosis0 aMagnetization Transfer Histogram Analysis of Segmented Normal Ap  c1999///  uhttps://tisat.inf.u-szeged.hu/en/node/107200302nas a2200085   4500008004100000245005800041210005800099260001200157856004700169       1999                        eng d00aNew Variants of a Method of MRI Scale Standardization0 aNew Variants of a Method of MRI Scale Standardization  c1999///  uhttps://tisat.inf.u-szeged.hu/en/node/1070